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Post by zanygame on Nov 19, 2022 22:11:08 GMT
Just read this and I thought about posters saying the NHS has got to big. So tell me who doesn't want this when it becomes available.
This is how an Alzheimer’s gene ravages the brain
No gene variant is a bigger risk factor for Alzheimer’s disease than one called APOE4. But exactly how the gene spurs brain damage has been a mystery.
A study has now linked APOE4 with faulty cholesterol processing in the brain, which in turn leads to defects in the insulating sheaths that surround nerve fibres and facilitate their electrical activity. Preliminary results hint that these changes could cause memory and learning deficits. And the work suggests that drugs that restore the brain’s cholesterol processing could treat the disease.
Insipid lipids
Inheriting a single copy of APOE4 raises the risk of developing Alzheimer’s around 3-fold; having two copies boosts the chances 8- to 12-fold. Interactions between the protein encoded by APOE4 and sticky plaques of amyloid — a substance tied to brain cell death — in the brain partially explain the connection. But those interactions are not the whole story.
As neuroscientist Li-Huei Tsai at the Massachusetts Institute of Technology (MIT) in Cambridge and her colleagues report today in Nature, APOE4 triggers insulation-making brain cells known as oligodendrocytes to accumulate the fatty molecule cholesterol — a type of lipid — in all the wrong places.
This interferes with the cells’ ability to cover nerve fibres in a protective wrapper made of a lipid-rich material called myelin. Electrical signalling in the brain then slows, and cognition usually suffers.
We have to pay more if we want this, fine if you don't just let the government know you're happy to be a dribbling idiot when the time comes.
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Post by Pacifico on Nov 19, 2022 22:55:03 GMT
LOL - I love your optimism that the NHS will be able to deliver, somehow I doubt that the 300,000 waiting for the NHS to deliver treatment for their cancer will be so confident..
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Post by totheleft3 on Nov 19, 2022 23:08:21 GMT
I think what zany is saying that the new treatment is a prevention rather then a cure like cancer treatment.
Think it would be easier to Administer like covid injections was what was administered though the NHS
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Post by zanygame on Nov 20, 2022 8:21:23 GMT
LOL - I love your optimism that the NHS will be able to deliver, somehow I doubt that the 300,000 waiting for the NHS to deliver treatment for their cancer will be so confident.. I'm thinking of all the new things you already get from your NHS each year. Here's a few you wont have even considered which have come forward in the last 5 years Neuro stimulation Regenerative medicine and therapies Personalized drugs and 3D printed drugs. Biotechnology for audio and vision restoration therapy Genomic editing. Wearable medical devices. 103 new drugs for cancer Crispr gene delivery Gene therapy viral Advanced MRI They all cost money and while they sometimes save money, overall they do not, they save lives. The argument that it can all be afforded by cutting waste is just stupid, we all live longer and we all need more and more medicines and treatments to maintain life and make it painless. Survival rates from Cancer are far higher than 30 years ago, why is that then? As for the waiting list, you make my point. WE NEED TO PAY MORE BECAUSE WE WANT MORE. |
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Post by Pacifico on Nov 20, 2022 8:28:15 GMT
LOL - I love your optimism that the NHS will be able to deliver, somehow I doubt that the 300,000 waiting for the NHS to deliver treatment for their cancer will be so confident.. I'm thinking of all the new things you already get from your NHS each year. Here's a few you wont have even considered which have come forward in the last 5 years Neuro stimulation Regenerative medicine and therapies Personalized drugs and 3D printed drugs. Biotechnology for audio and vision restoration therapy Genomic editing. Wearable medical devices. 103 new drugs for cancer Crispr gene delivery Gene therapy viral Advanced MRI They all cost money and while they sometimes save money, overall they do not, they save lives. The argument that it can all be afforded by cutting waste is just stupid, we all live longer and we all need more and more medicines and treatments to maintain life and make it painless. Survival rates from Cancer are far higher than 30 years ago, why is that then? As for the waiting list, you make my point. WE NEED TO PAY MORE BECAUSE WE WANT MORE. We are paying more and getting less. Real terms spending on NHS England this year is 12 per cent higher than in 2019-20. There are 13 per cent more doctors, including a tenth more consultants, 11 per cent more nurses, and 10 per cent more clinical support staff. Yet the NHS treated 5 per cent fewer people on waiting lists in the first nine months of 2022 – for hip replacements, cataracts, MRI scans and so on – than it did during the same period of 2019. |
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Post by zanygame on Nov 20, 2022 8:38:34 GMT
I'm thinking of all the new things you already get from your NHS each year. They all cost money and while they sometimes save money, overall they do not, they save lives. The argument that it can all be afforded by cutting waste is just stupid, we all live longer and we all need more and more medicines and treatments to maintain life and make it painless. Survival rates from Cancer are far higher than 30 years ago, why is that then? As for the waiting list, you make my point. WE NEED TO PAY MORE BECAUSE WE WANT MORE. We are paying more and getting less. Real terms spending on NHS England this year is 12 per cent higher than in 2019-20. There are 13 per cent more doctors, including a tenth more consultants, 11 per cent more nurses, and 10 per cent more clinical support staff. Yet the NHS treated 5 per cent fewer people on waiting lists in the first nine months of 2022 – for hip replacements, cataracts, MRI scans and so on – than it did during the same period of 2019. What a crazy simplistic argument. What about inflation and Covid. How many other things are they treating now instead of long term chronic treatments. We all know those are the things that get bumped when other diseases increase. This is a really poor response Pacifico. Really poor. |
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Post by Pacifico on Nov 21, 2022 11:44:32 GMT
We are paying more and getting less. Real terms spending on NHS England this year is 12 per cent higher than in 2019-20. There are 13 per cent more doctors, including a tenth more consultants, 11 per cent more nurses, and 10 per cent more clinical support staff. Yet the NHS treated 5 per cent fewer people on waiting lists in the first nine months of 2022 – for hip replacements, cataracts, MRI scans and so on – than it did during the same period of 2019. What a crazy simplistic argument. What about inflation and Covid. How many other things are they treating now instead of long term chronic treatments. We all know those are the things that get bumped when other diseases increase. This is a really poor response Pacifico. Really poor. The UK spending on healthcare is among the highest in europe - at some point you have to ask why that spending is not delivering. Your simplistic argument that all the system needs is more money thrown at it just does not work - we have been trying that response now for decades. Just last week the Government chucked another £7 Billion to the NHS with absolutely no idea where it is going to go and what benefits we would see for that money. |
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Post by Pacifico on Nov 21, 2022 11:49:28 GMT
We are paying more and getting less. Real terms spending on NHS England this year is 12 per cent higher than in 2019-20. There are 13 per cent more doctors, including a tenth more consultants, 11 per cent more nurses, and 10 per cent more clinical support staff. Yet the NHS treated 5 per cent fewer people on waiting lists in the first nine months of 2022 – for hip replacements, cataracts, MRI scans and so on – than it did during the same period of 2019. What a crazy simplistic argument. What about inflation and Covid. How many other things are they treating now instead of long term chronic treatments. We all know those are the things that get bumped when other diseases increase. This is a really poor response Pacifico. Really poor. We have been trying your way of just chucking ever greater amounts of money at the NHS for decades now and the service simply does not improve. Just last week the Government poured another £7 Billion into the NHS black hole with absolutely no idea where it was going or what improvements we might see from that cash. We now have ended up with one of the largest healthcare spends in Europe with arguably one of the worse services - that is what simply throwing money at the issue without any reform has given us. |
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Post by zanygame on Nov 21, 2022 19:31:40 GMT
What a crazy simplistic argument. What about inflation and Covid. How many other things are they treating now instead of long term chronic treatments. We all know those are the things that get bumped when other diseases increase. This is a really poor response Pacifico. Really poor. We have been trying your way of just chucking ever greater amounts of money at the NHS for decades now and the service simply does not improve. Just last week the Government poured another £7 Billion into the NHS black hole with absolutely no idea where it was going or what improvements we might see from that cash. We now have ended up with one of the largest healthcare spends in Europe with arguably one of the worse services - that is what simply throwing money at the issue without any reform has given us. Again you don't compare like with like. Tax in Germany is 37.5% of GDP and in the UK 33.3%. They don't fund their health service in the same way we do. UK spends $5,387 per capita. Germany $7,383. We are 12th in Europe. As I keep saying the reason the NHS cost more each year is that they keep adding things they can treat. But we don't spend more than others and its not a black hole. |
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Post by zanygame on Nov 21, 2022 19:38:34 GMT
And complaints about rainbow coloured zebra crossings being a waste of money. Because you don't think Lgbt matters.
But what if I suggested we stop funding the Chelsea pensioners as a waste of money? Oh know they're definitely worth the money.
Double standards.
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Post by Baron von Lotsov on Nov 21, 2022 23:17:11 GMT
Just read this and I thought about posters saying the NHS has got to big. So tell me who doesn't want this when it becomes available.
This is how an Alzheimer’s gene ravages the brain
No gene variant is a bigger risk factor for Alzheimer’s disease than one called APOE4. But exactly how the gene spurs brain damage has been a mystery.
A study has now linked APOE4 with faulty cholesterol processing in the brain, which in turn leads to defects in the insulating sheaths that surround nerve fibres and facilitate their electrical activity. Preliminary results hint that these changes could cause memory and learning deficits. And the work suggests that drugs that restore the brain’s cholesterol processing could treat the disease.
Insipid lipids
Inheriting a single copy of APOE4 raises the risk of developing Alzheimer’s around 3-fold; having two copies boosts the chances 8- to 12-fold. Interactions between the protein encoded by APOE4 and sticky plaques of amyloid — a substance tied to brain cell death — in the brain partially explain the connection. But those interactions are not the whole story.
As neuroscientist Li-Huei Tsai at the Massachusetts Institute of Technology (MIT) in Cambridge and her colleagues report today in Nature, APOE4 triggers insulation-making brain cells known as oligodendrocytes to accumulate the fatty molecule cholesterol — a type of lipid — in all the wrong places.
This interferes with the cells’ ability to cover nerve fibres in a protective wrapper made of a lipid-rich material called myelin. Electrical signalling in the brain then slows, and cognition usually suffers.
We have to pay more if we want this, fine if you don't just let the government know you're happy to be a dribbling idiot when the time comes. Very good, but the lady is Chinese. When are our people going to suss this stuff out?
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Post by Pacifico on Nov 22, 2022 8:13:57 GMT
We have been trying your way of just chucking ever greater amounts of money at the NHS for decades now and the service simply does not improve. Just last week the Government poured another £7 Billion into the NHS black hole with absolutely no idea where it was going or what improvements we might see from that cash. We now have ended up with one of the largest healthcare spends in Europe with arguably one of the worse services - that is what simply throwing money at the issue without any reform has given us. Again you don't compare like with like. Tax in Germany is 37.5% of GDP and in the UK 33.3%. They don't fund their health service in the same way we do. UK spends $5,387 per capita. Germany $7,383. We are 12th in Europe. As I keep saying the reason the NHS cost more each year is that they keep adding things they can treat. But we don't spend more than others and its not a black hole. In GDP terms we spend less than France, Germany and Austria but more than any other european country on healthcare. Personally I dont think we are getting a good deal - but if you are happy with it.. |
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Post by Paulus de B on Nov 22, 2022 14:56:46 GMT
Just read this and I thought about posters saying the NHS has got to big. So tell me who doesn't want this when it becomes available.
This is how an Alzheimer’s gene ravages the brain
No gene variant is a bigger risk factor for Alzheimer’s disease than one called APOE4. But exactly how the gene spurs brain damage has been a mystery.
A study has now linked APOE4 with faulty cholesterol processing in the brain, which in turn leads to defects in the insulating sheaths that surround nerve fibres and facilitate their electrical activity. Preliminary results hint that these changes could cause memory and learning deficits. And the work suggests that drugs that restore the brain’s cholesterol processing could treat the disease.
Insipid lipids
Inheriting a single copy of APOE4 raises the risk of developing Alzheimer’s around 3-fold; having two copies boosts the chances 8- to 12-fold. Interactions between the protein encoded by APOE4 and sticky plaques of amyloid — a substance tied to brain cell death — in the brain partially explain the connection. But those interactions are not the whole story.
As neuroscientist Li-Huei Tsai at the Massachusetts Institute of Technology (MIT) in Cambridge and her colleagues report today in Nature, APOE4 triggers insulation-making brain cells known as oligodendrocytes to accumulate the fatty molecule cholesterol — a type of lipid — in all the wrong places.
This interferes with the cells’ ability to cover nerve fibres in a protective wrapper made of a lipid-rich material called myelin. Electrical signalling in the brain then slows, and cognition usually suffers.
We have to pay more if we want this, fine if you don't just let the government know you're happy to be a dribbling idiot when the time comes. It's a non sequitur: you want this treatment, therefore you must support the current means of providing it. Do you suppose that such a thing will be accessible in countries that follow the Beveridge model of healthcare funding but not in those following the Bismarck model? If so, why? |
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Post by zanygame on Nov 22, 2022 20:24:27 GMT
Again you don't compare like with like. Tax in Germany is 37.5% of GDP and in the UK 33.3%. They don't fund their health service in the same way we do. UK spends $5,387 per capita. Germany $7,383. We are 12th in Europe. As I keep saying the reason the NHS cost more each year is that they keep adding things they can treat. But we don't spend more than others and its not a black hole. In GDP terms we spend less than France, Germany and Austria but more than any other european country on healthcare. Personally I dont think we are getting a good deal - but if you are happy with it.. Why on earth are you measuring it against GDP. It should be measured per capita. This is not about whether you're happy with it, its about what it should cost. |
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Post by zanygame on Nov 22, 2022 21:00:13 GMT
Just read this and I thought about posters saying the NHS has got to big. So tell me who doesn't want this when it becomes available.
This is how an Alzheimer’s gene ravages the brain
No gene variant is a bigger risk factor for Alzheimer’s disease than one called APOE4. But exactly how the gene spurs brain damage has been a mystery.
A study has now linked APOE4 with faulty cholesterol processing in the brain, which in turn leads to defects in the insulating sheaths that surround nerve fibres and facilitate their electrical activity. Preliminary results hint that these changes could cause memory and learning deficits. And the work suggests that drugs that restore the brain’s cholesterol processing could treat the disease.
Insipid lipids
Inheriting a single copy of APOE4 raises the risk of developing Alzheimer’s around 3-fold; having two copies boosts the chances 8- to 12-fold. Interactions between the protein encoded by APOE4 and sticky plaques of amyloid — a substance tied to brain cell death — in the brain partially explain the connection. But those interactions are not the whole story.
As neuroscientist Li-Huei Tsai at the Massachusetts Institute of Technology (MIT) in Cambridge and her colleagues report today in Nature, APOE4 triggers insulation-making brain cells known as oligodendrocytes to accumulate the fatty molecule cholesterol — a type of lipid — in all the wrong places.
This interferes with the cells’ ability to cover nerve fibres in a protective wrapper made of a lipid-rich material called myelin. Electrical signalling in the brain then slows, and cognition usually suffers.
We have to pay more if we want this, fine if you don't just let the government know you're happy to be a dribbling idiot when the time comes. It's a non sequitur: you want this treatment, therefore you must support the current means of providing it. Do you suppose that such a thing will be accessible in countries that follow the Beveridge model of healthcare funding but not in those following the Bismarck model? If so, why? I don't think the model matters so much as what you need to pay. The argument is that the NHS is a blackhole, my argument is that it keeps costing more for a reason, and that there is no need to change it. |
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