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Post by seniorcitizen007 on Feb 16, 2023 20:43:51 GMT
Several brands of jams that used Glucose-fructose syrup have recently removed it (including the cheap 39p jam sold by Tesco)
"After ingesting fructose, individuals with hereditary fructose intolerance may experience nausea, bloating, abdominal pain, diarrhea, vomiting, and low blood sugar."
"Fructose interferes with the body's ability to absorb tryptophan, the imbalance of neurotransmitters results in depression, irritability, and anxiety usually a day or two after ingestion."
Europeans and Africans have a significantly higher level of hereditary fructose intolerance than Asians.
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Post by johnofgwent on Feb 23, 2023 5:27:24 GMT
medlineplus.gov/genetics/condition/hereditary-fructose-intolerance/#frequencyNot quite, i think I was quite surprised to read your OP. I would have thought having spent six years working on the transport mechanisms that move various sugars across the gut wall and their subsequent metabolism in the liver, anything this disastrous ought to have appeared on my radar The above publication makes it clear that hereditary fructose intolerance is a quite fatal condition (like phenylketonuria, the inability to actually metabolise fructose and / or its metabolic products leads to a buildup of those products in the liver, causing cell damage, cell death, organ failure and death in pretty short order) The symptoms you describe are a separate condition called Fructose Malabsorbtion. This is described in the above reference. This is not a failure to manufacture the enzyme aldolase, the primary cause of hereditary intolerance and the organ failure that follows, but the utter failure of the intestine to permit the transport of the fruit sugar from the bowel into the gut. That would require a failure in the operation of the transport proteins in the cell membranes of the cells lining the intestine. These operate in the normal individual to accumulate various sugars against a concentration gradient and is an active transport process requiring the expenditure of energy through breaking adenosine triphosphate into adenosine diphosphate snd a single phosphate ion. I find that condition fascinating mainly because despite being one of only 13 people in the UK actively researching the uptake of sugars in the gut and their metabolism in the liver in 1981, i’d never heard of it until now. I am quite stunned to find that today this malabsorption problem hits 40% of western europeans. That indicates a massive problem given the evolutionary profile of homo sapiens as an omnivorous primate for which fruits were an essential element of the diet. This is not a fatal condition. The impact of it to sufferers though probably makes them wish it were.
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